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Mass Effect 3

The Reaper weapon nicknamed Blackstar is so advanced that Alliance scientists can only offer speculation about how this works. The gun appears to exploit an element zero core and mass effect fields to fire gravitational singularities--micro black holes--that revert to their natural lethality when they impact a solid object. Researchers theorize that the blast tears apart the strong nuclear forces that hold the target's atoms together, resulting in a localized fusion reaction in light atoms and a localized fission reaction in heavy atoms. If that hypothesis is correct, the weapon alters nuclei,, thus changing the chemical composition of the target. This destroys organic tissue, corrodes surviving armor, and leaves a visible trail of light-emitting particles.

Although some might argue that the Blackstar's single-launch capability makes it a liability, its capacity for utter destruction is essential when the user requires large-scale, instantaneous damage.